Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004912 | 0.79 | MAPT (0.48) | EGFRGAAMAPTALDH1A1MEN1 | |
| SCHEMBL24554040 | 0.76 | EGFR (0.40) | EGFRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29492714 | 0.76 | GAA (0.50) | EGFRGAAMAPTALDH1A1MEN1 | |
| SCHEMBL24270834 | 0.76 | GAA (0.50) | EGFRGAAMAPTALDH1A1MEN1 | |
| SCHEMBL4008794 | 0.74 | NPC1 (0.48) | ALDH1A1MEN1KMT2ARAB9AHPGD | |
| SCHEMBL19851138 | 0.73 | GAA (0.42) | EGFRGAAMAPTALDH1A1MEN1 | |
| SCHEMBL10813693 | 0.73 | HCAR3 (0.52) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2817959 | 0.72 | GAA (0.63) | EGFRGAAMAPTALDH1A1MEN1 | |
| SCHEMBL30896420 | 0.72 | MAPT (0.50) | EGFRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3838713 | 0.72 | EGFR (0.38) | EGFRGAAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |