Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3907896 | 0.84 | ENPP2 (0.47) | ENPP2GAARHEBOXER1EGFR | |
| SCHEMBL3896643 | 0.80 | ALDH1A1 (0.51) | GAAHTTCYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL28062862 | 0.78 | ENPP2 (0.43) | ENPP2GAARHEBOXER1MCL1 | |
| SCHEMBL9690808 | 0.77 | EGFR (0.68) | HTTEGFRALDH1A1 | |
| SCHEMBL19547601 | 0.74 | MCL1 (0.55) | ENPP2RHEBMCL1KMOMAT2A | |
| SCHEMBL9690435 | 0.74 | GABRP (0.54) | ENPP2MCL1KMOMAT2A | |
| SCHEMBL26631829 | 0.73 | NPSR1 (0.46) | ENPP2HTTKMOMAT2ACYP2C19 | |
| SCHEMBL28826067 | 0.72 | ENPP2 (0.44) | ENPP2RHEBMCL1KMOMAT2A | |
| SCHEMBL10751688 | 0.70 | PIM1 (0.38) | HTTEGFRALDH1A1LMNA | |
| SCHEMBL2085240 | 0.70 | KMT2A (0.48) | ENPP2GAAHTTCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874777-B1 | 1H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2011-06-08 | — | — | EP | disclosed |
| EP-1874777-A1 | H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | Sanofi-Aventis (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111648-A1 | H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-10-26 | — | — | WO | disclosed |