Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19250196 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL31329665 | 0.73 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL5529472 | 0.73 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL2435532 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL12101658 | 0.72 | KDM4E (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL2579591 | 0.72 | KDM4E (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL2580162 | 0.71 | ALDH1A1 (0.53) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL31434094 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL2578402 | 0.70 | KDM4E (0.52) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL | |
| SCHEMBL19249982 | 0.69 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969752-B2 | Inhibitors of HIF prolyl hydroxylase | MERCK SHARP & DOHME CORP. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | HIF1AN, HIF1A, EGLN2 | ALDH1A1 291/4885KDM4E 430/4885SMN1; SMN2 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.