Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19240341 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL19251331 | 0.83 | KDM4E (0.40) | KDM4EKDM1AMAOBRCOR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6602265 | 0.79 | SMN1; SMN2 (0.51) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL20288232 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL15710125 | 0.78 | MAPT (0.49) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL18901166 | 0.78 | NOS1 (0.45) | KDM4EALDH1A1SMN1; SMN2MAPTROCK2 | |
| SCHEMBL3140637 | 0.77 | APP (0.46) | KDM1AMAOBRCOR1 | |
| SCHEMBL24506828 | 0.75 | SMN1; SMN2 (0.57) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL21257469 | 0.75 | SMN1; SMN2 (0.61) | KDM4EALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL17115656 | 0.74 | SMN1; SMN2 (0.44) | KDM4EALDH1A1LMNASMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | HSPA2, HSP90AA1, HSP90AB1 | KDM4E 4395/4885KDM1A 3544/4885MAOB 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.