Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710125 | 0.85 | MAPT (0.49) | SMN1; SMN2KDM4ELMNAUSP2ALDH1A1 | |
| SCHEMBL28030656 | 0.84 | IRAK4 (0.52) | SMN1; SMN2KDM4ELMNAKCNH2OPRM1 | |
| SCHEMBL10131967 | 0.78 | NEK2 (0.43) | SMN1; SMN2LMNAEPHX2USP2MAPT | |
| SCHEMBL10391003 | 0.77 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL6602265 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ELMNAUSP2ALDH1A1 | |
| SCHEMBL18901166 | 0.76 | NOS1 (0.45) | SMN1; SMN2KDM4EEPHX2ALDH1A1MAPT | |
| SCHEMBL4529690 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPTSMYD3 | |
| SCHEMBL12472792 | 0.76 | MAPT (0.51) | KDM4ELMNAEPHX2USP2ALDH1A1 | |
| SCHEMBL6509671 | 0.75 | ALDH1A1 (0.46) | GRIA2ALDH1A1 | |
| SCHEMBL17303754 | 0.75 | KDM4E (0.58) | SMN1; SMN2KDM4ELMNAEPHX2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143340-A1 | COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |