Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13296397 | 0.79 | POLB (0.49) | NPSR1POLBATMLMNAALDH1A1 | |
| SCHEMBL1467165 | 0.78 | LMNA (0.74) | LMNACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL19240319 | 0.77 | LMNA (0.39) | NPSR1POLBATMLMNAALDH1A1 | |
| SCHEMBL9362871 | 0.77 | CHRM1 (0.40) | LMNAALDH1A1CHRM1CHRM2CHRM4 | |
| Bromide SCHEMBL22034526 | 0.76 | LMNA (0.70) | LMNACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL21191969 | 0.76 | LMNA (0.70) | ATMLMNACHRM1CHRM2CHRM4 | |
| SCHEMBL13956300 | 0.76 | NPSR1 (0.48) | NPSR1POLBATMLMNAALDH1A1 | |
| SCHEMBL8063896 | 0.74 | NPSR1 (0.47) | NPSR1POLBATMLMNAALDH1A1 | |
| SCHEMBL2386769 | 0.74 | LMNA (0.41) | NPSR1POLBLMNAALDH1A1CHRM1 | |
| SCHEMBL1469845 | 0.73 | POLB (0.59) | POLBLMNAALDH1A1USP2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | HSPA2, HSP90AA1, HSP90AB1 | NPSR1 1960/4885POLB 3788/4885ATM 3397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.