Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778645 | 0.88 | POLB (0.45) | POLBMAPK1SMN1; SMN2KDM4EPIK3CA | |
| SCHEMBL22778684 | 0.85 | HRH3 (0.43) | KDM4EHRH3 | |
| SCHEMBL9908476 | 0.83 | POLB (0.53) | POLBMAPK1SMN1; SMN2KDM4EPIK3CA | |
| SCHEMBL10331986 | 0.80 | ALDH1A1 (0.50) | POLBSMN1; SMN2KDM4EKMT2ACNR2 | |
| SCHEMBL13662110 | 0.79 | IMPDH2 (0.39) | MAPK1KDM4EPIK3CAPIK3R1KMT2A | |
| SCHEMBL14236595 | 0.77 | SYK (0.45) | POLBMAPK1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL10272665 | 0.76 | POLB (0.53) | POLBMAPK1SMN1; SMN2KDM4EPIK3CA | |
| SCHEMBL19965625 | 0.76 | ACHE (0.46) | MAPK1SMN1; SMN2KDM4EPIK3CAPIK3R1 | |
| SCHEMBL24590359 | 0.75 | POLB (0.49) | POLBMAPK1SMN1; SMN2KDM4EPIK3CA | |
| SCHEMBL8375217 | 0.75 | MAPT (0.49) | POLBMAPK1SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |