Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 3/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22962251 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22962004 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22778647 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22962144 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22962335 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22962072 | 0.85 | GNAI3 (0.47) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL24788378 | 0.84 | SPHK1 (0.34) | GNAI3GNAO1GNAI1FDPSSPHK1 | |
| SCHEMBL18976271 | 0.84 | GNAI3 (0.37) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL22778689 | 0.83 | GNAI3 (0.46) | GNAI3GNAO1GNAI1OPRM1FDPS | |
| SCHEMBL23865829 | 0.83 | ALDH1A1 (0.40) | GNAI3GNAO1GNAI1OPRM1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |