Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18935594 | 0.86 | CYP11B2 (0.40) | CYP11B2RAF1CYP19A1CYP11B1PTGER4 | |
| SCHEMBL19592946 | 0.82 | CNR2 (0.38) | CYP11B2RAF1CYP11B1CYP1A2METAP2 | |
| SCHEMBL9967844 | 0.81 | KIF11 (0.44) | CYP11B2RAF1CYP19A1CYP11B1CYP1A2 | |
| SCHEMBL19251665 | 0.79 | CYP11B2 (0.39) | CYP11B2RAF1CYP11B1PTGER4CYP1A2 | |
| SCHEMBL14822598 | 0.78 | CYP11B2 (0.55) | CYP11B2RAF1CYP11B1 | |
| SCHEMBL22338688 | 0.78 | CYP1A2 (0.40) | CYP11B2RAF1CYP11B1CYP1A2METAP2 | |
| SCHEMBL22303444 | 0.75 | CYP11B2 (0.41) | CYP11B2RAF1CYP11B1CYP1A2METAP2 | |
| SCHEMBL14809739 | 0.75 | CYP11B2 (0.37) | CYP11B2RAF1CYP19A1CYP11B1CYP1A2 | |
| SCHEMBL2749165 | 0.73 | CYP1A2 (0.49) | CYP11B2CYP11B1CYP1A2METAP2GRIN1 | |
| SCHEMBL30133235 | 0.73 | CYP1A2 (0.49) | CYP11B2CYP11B1CYP1A2METAP2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |