Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 19/20 | 0.41 |
| ▸ | CNR1 | P21554 | 18/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12459166 | 0.81 | ALDH1A1 (0.41) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL23271199 | 0.68 | TDP2 (0.42) | SMN1; SMN2 | |
| SCHEMBL29683177 | 0.68 | TDP2 (0.42) | SMN1; SMN2 | |
| SCHEMBL16006554 | 0.67 | PBRM1 (0.42) | LMNA | |
| SCHEMBL14992095 | 0.67 | PARP1 (0.45) | — | |
| SCHEMBL29226241 | 0.67 | TGM2 (0.49) | — | |
| SCHEMBL30900443 | 0.67 | TGM2 (0.49) | — | |
| SCHEMBL30095473 | 0.67 | CA9 (0.39) | NPC1LMNAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL17695142 | 0.66 | HPGD (0.57) | LMNA | |
| SCHEMBL18410997 | 0.64 | CNR2 (0.43) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |