Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924610 | 0.91 | MAPT (0.52) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL1926602 | 0.90 | KDM4E (0.46) | MEN1KMT2AMAPTGAAPOLB | |
| SCHEMBL1924361 | 0.89 | KMT2A (0.46) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL1925383 | 0.88 | RAB9A (0.53) | MEN1KMT2AMAPTTP53SMN1; SMN2 | |
| SCHEMBL1926895 | 0.87 | MAPT (0.41) | MEN1KMT2AMAPTTP53MAPK1 | |
| SCHEMBL1923987 | 0.86 | TSHR (0.50) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL1925623 | 0.84 | MEN1 (0.54) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL1923912 | 0.81 | KDR (0.48) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL1924934 | 0.81 | MAPK1 (0.55) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL1924884 | 0.80 | MEN1 (0.42) | MEN1KMT2AMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |