Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925163 | 0.88 | MEN1 (0.50) | RAB9ASMN1; SMN2ROCK2MAPTCA12 | |
| SCHEMBL1924610 | 0.88 | MAPT (0.52) | RAB9ASMN1; SMN2MAPTCA12CA1 | |
| SCHEMBL1924361 | 0.88 | KMT2A (0.46) | RAB9AROCK2MAPTNPC1MEN1 | |
| SCHEMBL1925746 | 0.88 | ITGB1 (0.52) | RAB9ASMN1; SMN2MAPTNPC1MEN1 | |
| SCHEMBL1926602 | 0.86 | KDM4E (0.46) | RAB9ASMN1; SMN2ROCK2LIMK1MAPT | |
| SCHEMBL1926895 | 0.86 | MAPT (0.41) | RAB9ASMN1; SMN2ROCK2LIMK1MAPT | |
| SCHEMBL1925337 | 0.86 | PKM (0.47) | RAB9ASMN1; SMN2MAPTNPC1CA12 | |
| SCHEMBL1923987 | 0.85 | TSHR (0.50) | RAB9ASMN1; SMN2ROCK2LIMK1MAPT | |
| SCHEMBL1924115 | 0.84 | RAB9A (0.58) | RAB9ASMN1; SMN2L3MBTL1ROCK2LIMK1 | |
| SCHEMBL1924459 | 0.83 | KDM4E (0.46) | RAB9AROCK2MAPTNPC1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |