Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924884 | 0.93 | MEN1 (0.42) | KDRPDGFRBAKT2MAPTCSF1R | |
| SCHEMBL1924534 | 0.90 | AURKA (0.44) | KDRPDGFRBAKT2MAPTCSF1R | |
| SCHEMBL1924620 | 0.90 | CSF1R (0.53) | KDRPDGFRBMAPTCSF1RFLT1 | |
| SCHEMBL1924876 | 0.89 | AKT2 (0.42) | KDRPDGFRBAKT2CSF1RFLT1 | |
| SCHEMBL1924464 | 0.89 | ALDH1A1 (0.38) | KDRPDGFRBAKT2MAPTFLT3 | |
| SCHEMBL1926602 | 0.88 | KDM4E (0.46) | KDRPDGFRBMAPTFLT3FFAR1 | |
| SCHEMBL1925746 | 0.88 | ITGB1 (0.52) | KDRPDGFRBMAPTFLT3MEN1 | |
| SCHEMBL1924610 | 0.87 | MAPT (0.52) | MAPTPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1925334 | 0.86 | EPHX2 (0.48) | KDRKIF11MAPTFFAR1STING1 | |
| SCHEMBL1924361 | 0.86 | KMT2A (0.46) | MAPTPOLBMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |