Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.53 |
| ▸ | RARG | P13631 | 10/20 | 0.53 |
| ▸ | RARA | P10276 | 8/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | HNF4A | P41235 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19342932 | 0.88 | RARB (0.68) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL4946746 | 0.79 | RARB (0.43) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL19342986 | 0.79 | RARB (0.62) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6378170 | 0.78 | RARB (0.52) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6340282 | 0.78 | RARB (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7751295 | 0.77 | RARB (0.51) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL2912775 | 0.77 | RARB (0.51) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL15524271 | 0.77 | HNF4A (0.61) | CYP3A4HNF4ACA12ALDH1A1CA1 | |
| SCHEMBL6260318 | 0.76 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1991598 | 0.76 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355067-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPEMENT (FR) | 2021-11-18 | — | — | US | disclosed |
| US-10995052-B2 | Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-05-04 | — | — | US | disclosed |
| US-10377694-B2 | Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-08-13 | — | — | US | disclosed |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-03-22 | — | — | US | disclosed |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-03-22 | — | — | US | disclosed |
| WO-2017134513-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995052-B2 | Biaromatic propynyl compounds, pharmaceutical and cosmetic compositions containing same, and uses thereof | TYR, MITF, PAOX | RARB 1278/4885RARG 909/4885RARA 974/4885 |
| US-20180079707-A1 | NEW BI-AROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND USES THEREOF | TYR, MITF, PAH | RARB 431/4885RARG 432/4885RARA 406/4885 |
| US-20210355067-A1 | NOVEL BIAROMATIC PROPYNYL COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME, AND USES THEREOF | MITF, TYR, PAOX | RARB 1410/4885RARG 1171/4885RARA 1162/4885 |
| US-10377694-B2 | Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | TYR, MITF, PAH | RARB 510/4885RARG 506/4885RARA 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.