Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 6/20 | 0.59 |
| ▸ | BCHE | P06276 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CFTR | P13569 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.59 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778774 | 0.90 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL12457528 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL17229278 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL24329595 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5519389 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5509709 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL17221319 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL12459162 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL16330612 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL11085523 | 0.78 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10865216-B2 | Tricyclic Gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-12-15 | — | — | US | disclosed |
| US-10858360-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-12-08 | — | — | US | disclosed |
| US-20170369498-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-12-28 | — | — | US | disclosed |
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858360-B2 | Tricyclic gyrase inhibitors | TOP1, TOP2A, TOP2B | SMN1; SMN2 3895/4885ALDH1A1 1898/4885KDM4E 2371/4885 |
| US-20170369498-A1 | TRICYCLIC GYRASE INHIBITORS | TOP1, TOP2A, TOP2B | SMN1; SMN2 3895/4885ALDH1A1 1898/4885KDM4E 2371/4885 |
| US-10865216-B2 | Tricyclic Gyrase inhibitors | TOP1, TOP2A, TOP2B | SMN1; SMN2 3995/4885ALDH1A1 1726/4885KDM4E 2335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.