Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455351 | 0.90 | KDM4E (0.53) | HDAC6KDM4EGPR3HTR6AHR | |
| SCHEMBL27673186 | 0.89 | KDM4E (0.52) | HDAC6KDM4EGPR3HTR6AHR | |
| Iodide SCHEMBL4717590 | 0.89 | KDM4E (0.52) | HDAC6KDM4EGPR3HTR6AHR | |
| Hydrochloric Acid SCHEMBL3881151 | 0.89 | KDM4E (0.52) | HDAC6KDM4EGPR3HTR6AHR | |
| Hydrochloric Acid SCHEMBL27669383 | 0.87 | KDM4E (0.50) | HDAC6KDM4EGPR3HTR6AHR | |
| Hydrochloric Acid SCHEMBL28761791 | 0.87 | KDM4E (0.50) | HDAC6KDM4EGPR3HTR6AHR | |
| Toluene SCHEMBL19252764 | 0.84 | KDM4E (0.44) | KDM4EGPR3HTR6NPC1RAB9A | |
| Acetic Acid SCHEMBL18155003 | 0.83 | KDM4E (0.43) | KDM4EGPR3HTR6RAD52SMARCA2 | |
| SCHEMBL574757 | 0.82 | KDM4E (0.42) | KDM4EGPR3HTR6NPC1RAB9A | |
| Formic Acid SCHEMBL3882912 | 0.81 | KDM4E (0.44) | HDAC6KDM4EGPR3HTR6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170239237-A1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE MONTPELLIER (FR) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170239237-A1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | HTR6, HTR2C, HTR3B | HDAC6 511/4885KDM4E 1278/4885GPR3 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.