Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455351 | 0.90 | KDM4E (0.53) | KDM4EGPR3HTR6PARP1PDPK1 | |
| Iodide SCHEMBL4717590 | 0.89 | KDM4E (0.52) | KDM4EGPR3HTR6PARP1PDPK1 | |
| SCHEMBL27673186 | 0.89 | KDM4E (0.52) | KDM4EGPR3HTR6PARP1PDPK1 | |
| Hydrochloric Acid SCHEMBL3881151 | 0.89 | KDM4E (0.52) | KDM4EGPR3HTR6PARP1PDPK1 | |
| Hydrochloric Acid SCHEMBL28761791 | 0.87 | KDM4E (0.50) | KDM4EGPR3HTR6PARP1PDPK1 | |
| Hydrochloric Acid SCHEMBL27669383 | 0.87 | KDM4E (0.50) | KDM4EGPR3HTR6PARP1PDPK1 | |
| Acetic Acid SCHEMBL18155003 | 0.86 | KDM4E (0.43) | KDM4EGPR3HTR6ALOX15 | |
| SCHEMBL574757 | 0.85 | KDM4E (0.42) | KDM4EGPR3ERN1HTR6GABRA1 | |
| Trifluoroacetic Acid SCHEMBL3937089 | 0.82 | KDM4E (0.40) | KDM4EGPR3HTR6ALOX15 | |
| Chlorobenzene SCHEMBL19252790 | 0.81 | HDAC6 (0.46) | KDM4EGPR3HTR6SMN1; SMN2TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086542-A1 | TOPICAL FORMULATIONS | Helperby Therapeutics Limited (GB) | 2009-08-12 | — | — | EP | disclosed |
| EP-1945211-A1 | USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | Helperby Therapeutics Limited (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008056151-A1 | TOPICAL FORMULATIONS | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |
| WO-2007054693-A1 | USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | HELPERBY THERAPEUTICS LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |