Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Dextrose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HK1 | P19367 | 2/20 | 0.53 |
| ▸ | HK2 | P52789 | 2/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.51 |
| ▸ | LGALS9 | O00182 | 2/20 | 0.48 |
| ▸ | LGALS1 | P09382 | 2/20 | 0.48 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.48 |
| ▸ | LGALS7; LGALS7B | P47929 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL9397547 | 0.93 | PYGL (0.53) | HK1HK2PYGL | |
| Ribose (Furanose) SCHEMBL502653 | 0.87 | HK1 (0.53) | HK1HK2LGALS9LGALS1LGALS3 | |
| Dextrose SCHEMBL28181167 | 0.84 | HK1 (0.59) | HK1HK2LGALS9LGALS1LGALS3 | |
| Ribose (Furanose) SCHEMBL19717961 | 0.84 | NAPRT (0.53) | HK1HK2PYGLALDH1A1 | |
| Benzoic Acid SCHEMBL6399739 | 0.84 | PYGL (0.46) | HK1HK2PYGLLGALS9LGALS1 | |
| Dextrose SCHEMBL28858708 | 0.83 | TSHR (0.54) | HK1HK2LGALS9LGALS1LGALS3 | |
| Beta-D-Glucose SCHEMBL28005376 | 0.83 | HK1 (0.57) | HK1HK2LGALS9LGALS1LGALS3 | |
| D-Mannose SCHEMBL1660734 | 0.82 | SLC5A2 (0.64) | HK1HK2PYGL | |
| Ribose (Furanose) SCHEMBL502577 | 0.82 | ALDH1A1 (0.58) | HK1HK2PYGLLGALS9LGALS1 | |
| B-D-Galactose SCHEMBL28251165 | 0.82 | LGALS1 (0.52) | HK1HK2LGALS9LGALS1LGALS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834533-B2 | Process for preparing SGLT2 inhibitors and intermediates thereof | SCINOPHARM TAIWAN, LTD. (TW) | 2017-12-05 | — | — | US | disclosed |
| US-20170240520-A1 | PROCESS FOR PREPARING SGLT2 INHIBITORS AND INTERMEDIATES THEREOF | SCINOPHARM TAIWAN, LTD. (TW) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240520-A1 | PROCESS FOR PREPARING SGLT2 INHIBITORS AND INTERMEDIATES THEREOF | SLC5A2, SLC5A1, DPP4 | HK1 171/4885HK2 92/4885PYGL 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.