Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925624 | 0.93 | ALDH1A1 (0.46) | POLBNPSR1ALDH1A1PIM1MAPT | |
| SCHEMBL1926058 | 0.91 | NPSR1 (0.47) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL6493868 | 0.90 | NPSR1 (0.46) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL1924400 | 0.84 | ALDH1A1 (0.47) | POLBNPSR1ALDH1A1MAPTMAOA | |
| SCHEMBL1925489 | 0.83 | ALDH1A1 (0.46) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL1925814 | 0.77 | POLB (0.56) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL1925754 | 0.77 | CES2 (0.41) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL14101816 | 0.76 | ALDH1A1 (0.48) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL20476879 | 0.74 | TSHR (0.51) | POLBNPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL2175971 | 0.73 | CA12 (0.59) | POLBALDH1A1PIM1MAPTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1431293-B1 | WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2011-06-08 | — | — | EP | disclosed |