Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925762 | 0.93 | CES2 (0.44) | CES2CES1POLBNPSR1RAB9A | |
| SCHEMBL30329906 | 0.81 | ABCB11 (0.42) | POLBNPSR1MAPTACKR3ALDH1A1 | |
| SCHEMBL22710886 | 0.81 | ABCB11 (0.42) | POLBNPSR1MAPTACKR3ALDH1A1 | |
| SCHEMBL1926058 | 0.78 | NPSR1 (0.47) | CES2CES1POLBNPSR1NPC1 | |
| SCHEMBL1925342 | 0.77 | POLB (0.46) | POLBNPSR1MAPTHTTALDH1A1 | |
| SCHEMBL6493868 | 0.77 | NPSR1 (0.46) | POLBNPSR1NPC1MAPTHTT | |
| SCHEMBL8639619 | 0.74 | PLOD2 (0.46) | CES2CES1POLBRAB9ANPC1 | |
| SCHEMBL9234534 | 0.74 | CES2 (0.46) | CES2CES1POLBNPSR1RAB9A | |
| SCHEMBL2080446 | 0.74 | CES2 (0.49) | CES2CES1POLBNPSR1RAB9A | |
| SCHEMBL367075 | 0.73 | TSHR (0.57) | CES2CES1POLBNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1431293-B1 | WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2011-06-08 | — | — | EP | disclosed |