SCHEMBL1925368

SCHEMBL1925368

CNc1ccc2c(c1)Sc1cc(NC)ccc1N2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 8/20 0.50
NOX1 Q9Y5S8 10/20 0.43
MAPT P10636 6/20 0.43
GAA P10253 5/20 0.43
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
TDP1 Q9NUW8 4/20 0.43
MAPK1 P28482 3/20 0.43
LMNA P02545 2/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ALOX15 P16050 3/20 0.41
BCHE P06276 2/20 0.41
ACHE P22303 2/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41
CYP3A4 P08684 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
ALOX12 P18054 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20488743 0.91 NOX1 (0.59) SNCANOX1MAPTGAAMEN1
SCHEMBL11148979 0.89 SNCA (0.42) SNCANOX1MAPTGAAMEN1
SCHEMBL12038535 0.87 SNCA (0.40) SNCANOX1MAPTGAAMEN1
SCHEMBL25913327 0.80 NOX1 (0.59) SNCANOX1MAPTGAAMEN1
SCHEMBL4092501 0.80 MAPT (0.41) SNCANOX1MAPTGAAMEN1
SCHEMBL20398349 0.80 MAPT (0.48) SNCANOX1MAPTGAAMEN1
SCHEMBL22562767 0.79 SNCA (0.46) SNCANOX1MAPTGAAMEN1
SCHEMBL20398354 0.79 SNCA (0.46) SNCANOX1MAPTGAAMEN1
SCHEMBL81579 0.79 SNCA (0.46) SNCANOX1MAPTGAAMEN1
SCHEMBL20495639 0.78 MAPT (0.37) SNCANOX1MAPTGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250222006-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2025-07-10 US disclosed
US-20240115580-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2024-04-11 US disclosed
US-11878021-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2024-01-23 US disclosed
EP-3121169-B1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LAB LTD (SG) 2022-02-09 EP disclosed
US-20210322435-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS Wis Ta Laboratories Ltd. (SG) 2021-10-21 US disclosed
US-11045477-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2021-06-29 US disclosed
WO-2020243008-A1 SENSORS AND METHODS FOR RAPID MICROBIAL DETECTION BAMBU VAULT LLC (US) 2020-12-03 WO disclosed
US-20200261465-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2020-08-20 US disclosed
US-20180263999-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2018-09-20 US disclosed
US-9980971-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2018-05-29 US disclosed
US-8440821-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2013-05-14 US disclosed
EP-2305823-B1 Materials and methods relating to protein aggregation in neurodegenerative disease WISTA LAB LTD (SG) 2013-03-27 EP disclosed
EP-2457904-A1 Methods of synthesis and/or purification of diaminophenothiazinium compounds Wista Laboratories Ltd. (SG) 2012-05-30 EP disclosed
EP-2457905-A1 Methods of synthesis and/or purification of diaminophenothiazinium compounds Wista Laboratories Ltd. (SG) 2012-05-30 EP disclosed
US-20110294795-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. 2011-12-01 US disclosed
US-7956183-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2011-06-07 US disclosed
EP-1352077-B1 MATERIALS AND METHODS RELATING TO PROTEIN AGGREGATION IN NEURODEGENERATIVE DISEASE WISTA LAB LTD (SG) 2010-10-06 EP disclosed
US-20090259040-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2009-10-15 US disclosed
EP-2057136-A2 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS Wista Laboratories Ltd. (SG) 2009-05-13 EP disclosed
WO-2008007074-A2 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2008-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180263999-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-20250222006-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-20210322435-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-11045477-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-20090259040-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS PARK7, SNCA, GRN SNCA 2/4885NOX1 3287/4885MAPT 4/4885
US-20240115580-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-11878021-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885
US-20110294795-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MMAB, MB, ABCB7 SNCA 1425/4885NOX1 3149/4885MAPT 1569/4885
US-20200261465-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MB, TPMT, HBB SNCA 173/4885NOX1 1655/4885MAPT 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.