Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11792666 | 0.80 | SIGMAR1 (0.48) | SIGMAR1CASRPOLBKDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL11350504 | 0.76 | SIGMAR1 (0.44) | SIGMAR1CASRPOLBKDM4ECYP3A4 | |
| SCHEMBL21228075 | 0.74 | SIGMAR1 (0.53) | SIGMAR1CASRPOLBKDM4ECYP3A4 | |
| SCHEMBL794607 | 0.72 | SIGMAR1 (0.41) | SIGMAR1CYP3A4 | |
| SCHEMBL15671412 | 0.72 | ALDH1A1 (0.46) | SIGMAR1MAPTMEN1KMT2AATM | |
| SCHEMBL19853394 | 0.72 | SIGMAR1 (0.57) | SIGMAR1CASRPOLBKDM4ECYP3A4 | |
| SCHEMBL16714808 | 0.71 | SIGMAR1 (0.56) | SIGMAR1CASRPOLBMEN1KMT2A | |
| SCHEMBL16714805 | 0.71 | SIGMAR1 (0.56) | SIGMAR1CASRPOLBMEN1KMT2A | |
| SCHEMBL9079776 | 0.71 | KDM4E (0.50) | SIGMAR1CASRKDM4EBCHETDP1 | |
| SCHEMBL13858736 | 0.70 | SIGMAR1 (0.59) | SIGMAR1CASRPOLBKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022204150-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CNS DISORDERS | BLUE OAK PHARMACEUTICALS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| WO-2021195183-A1 | COMPOSITIONS AND METHODS FOR INHIBITING PROTEIN EMBRYONIC ECTODERM DEVELOPMENT ACTIVITY AND TREATING DISEASE | EXO THERAPEUTICS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| EP-3486231-B1 | PYRROLIDINE DERIVATIVE SERVING AS PPAR AGONIST | GUANGDONG RAYNOVENT BIOTECH CO LTD (CN) | 2020-05-20 | — | — | EP | disclosed |
| US-10532985-B2 | Heterocycle and carbocycle derivatives having TRKA inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2020-01-14 | — | — | US | disclosed |
| US-20190225597-A1 | PYRROLIDINE DERIVATIVES AS PPAR AGONISTS | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-07-25 | — | — | US | disclosed |
| EP-3486231-A1 | PYRROLIDINE DERIVATIVE SERVING AS PPAR AGONIST | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-05-22 | — | — | EP | disclosed |
| US-10160727-B2 | Heterocycle and carbocycle derivatives having TrkA inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2018-12-25 | — | — | US | disclosed |
| US-20170240512-A1 | HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160727-B2 | Heterocycle and carbocycle derivatives having TrkA inhibitory activity | NR5A2, NPY5R, MC5R | SIGMAR1 947/4885CASR 582/4885POLB 3706/4885 |
| US-10532985-B2 | Heterocycle and carbocycle derivatives having TRKA inhibitory activity | NR5A2, NPY5R, MC5R | SIGMAR1 947/4885CASR 582/4885POLB 3706/4885 |
| US-20170240512-A1 | HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | NR5A2, NPY5R, MC5R | SIGMAR1 947/4885CASR 582/4885POLB 3706/4885 |
| US-20190225597-A1 | PYRROLIDINE DERIVATIVES AS PPAR AGONISTS | PPARD, PPARA, PPARG | SIGMAR1 831/4885CASR 2347/4885POLB 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.