Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477819 | 0.84 | SMN1; SMN2 (0.40) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL17480789 | 0.82 | F11 (0.39) | KMT2AMAPTSMN1; SMN2KDM4EGCK | |
| SCHEMBL17480682 | 0.75 | SLC7A5 (0.38) | MEN1KMT2AMAPTMAPK1B3GNT2 | |
| SCHEMBL19253879 | 0.73 | CYP1A2 (0.39) | MMP2MMP9MMP8MMP13MEN1 | |
| SCHEMBL17480786 | 0.71 | F11 (0.43) | F11KLKB1 | |
| SCHEMBL407841 | 0.71 | KDM4E (0.48) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL17295757 | 0.70 | F11 (0.46) | MMP1MMP3MMP7MEN1KMT2A | |
| SCHEMBL17477806 | 0.70 | AAK1 (0.47) | KMT2AMAPTMAPK1KDM4EALDH1A1 | |
| SCHEMBL19138146 | 0.70 | FPR2 (0.35) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27157157 | 0.70 | TLR8 (0.35) | MMP2MMP9MMP8MMP13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180327-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2019-05-08 | — | — | EP | disclosed |
| US-10011585-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170240523-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240523-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | MMP2 80/4885MMP9 81/4885MMP8 78/4885 |
| US-10011585-B2 | Factor XIa inhibitors | F11, SERPINC1, TFPI | MMP2 80/4885MMP9 81/4885MMP8 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.