Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236334 | 0.83 | OPRM1 (0.31) | LMNACYP2C9 | |
| SCHEMBL25460609 | 0.78 | LMNA (0.36) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8373572 | 0.76 | SLC6A4 (0.40) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL22025699 | 0.75 | LMNA (0.33) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8373088 | 0.73 | LMNA (0.32) | LMNACYP2C9SLC6A4SLC6A3 | |
| SCHEMBL3823535 | 0.73 | ALDH1A1 (0.34) | — | |
| SCHEMBL25460456 | 0.72 | ALDH1A1 (0.33) | LMNACYP2C9SLC6A4SLC6A3 | |
| SCHEMBL8079753 | 0.70 | LMNA (0.42) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL14298073 | 0.70 | LMNA (0.42) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4743604 | 0.69 | LMNA (0.46) | LMNACYP2C9SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732029-B2 | Nitroso compounds as nitroxyl donors and methods of use thereof | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-08-15 | — | — | US | disclosed |