Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19224497 | 0.79 | GABRP (0.47) | RIPK1KDM4EALDH1A1HPGDTTR | |
| SCHEMBL28695661 | 0.79 | GABRP (0.47) | RIPK1KDM4EALDH1A1HPGDTTR | |
| SCHEMBL19207538 | 0.79 | RIPK1 (0.53) | RIPK1CCKBRCCKAR | |
| SCHEMBL19207640 | 0.79 | RIPK1 (0.53) | RIPK1CCKBRCCKAR | |
| SCHEMBL21339127 | 0.78 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| Hydrochloric Acid SCHEMBL19207753 | 0.78 | GABRP (0.46) | RIPK1KDM4EALDH1A1HPGDTTR | |
| Hydrochloric Acid SCHEMBL19207755 | 0.78 | GABRP (0.46) | RIPK1KDM4EALDH1A1HPGDTTR | |
| SCHEMBL8274783 | 0.71 | RIPK1 (0.41) | RIPK1ALDH1A1ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL4890187 | 0.70 | RIPK1 (0.41) | RIPK1ALDH1A1ADRA2AADRA2BADRA2C | |
| SCHEMBL19255334 | 0.69 | RIPK1 (0.57) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |