Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750687 | 0.98 | KMT2A (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11729721 | 0.95 | KMT2A (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7677787 | 0.84 | SMN1; SMN2 (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4265834 | 0.81 | MEN1 (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8298958 | 0.79 | KMT2A (0.41) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1716137 | 0.77 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9471345 | 0.77 | MAPT (0.40) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30503600 | 0.75 | GPR35 (0.44) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2594851 | 0.75 | GPR35 (0.44) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9177580 | 0.75 | MAPT (0.41) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732066-B2 | Heterocyclic derivative and pharmaceutical drug | NIPPON SHINY AKU CO., LTD. (JP) | 2017-08-15 | — | — | US | disclosed |