Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.34 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17321229 | 0.82 | CREBBP (0.48) | HTR5ACES1CACNG8BLMSMYD3 | |
| SCHEMBL12345900 | 0.78 | ADRA2A (0.38) | HTR1AHTR7MEN1KMT2ABRD4 | |
| Hydrochloric Acid SCHEMBL2236148 | 0.77 | ANPEP (0.39) | HTR1AHTR7BRD4CREBBP | |
| SCHEMBL15964565 | 0.76 | CA2 (0.39) | HTR5ACA2CES1CACNB4CACNA1A | |
| SCHEMBL24029073 | 0.75 | HTR5A (0.47) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL1562673 | 0.74 | PARP1 (0.49) | BLMMEN1GRIN2DLMNACYP3A4 | |
| SCHEMBL1562671 | 0.74 | PARP1 (0.49) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL2235593 | 0.73 | PARP1 (0.47) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL4797679 | 0.73 | PARP1 (0.47) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL2235597 | 0.73 | PARP1 (0.47) | BLMMEN1GRIN2DLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |