Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566726 | 0.93 | ALDH1A1 (0.52) | MAPTALDH1A1TSHRCYP3A4KMT2A | |
| SCHEMBL27340179 | 0.89 | MAPT (0.48) | MAPTALDH1A1TSHRCYP3A4KMT2A | |
| SCHEMBL29594753 | 0.86 | KMT2A (0.56) | MAPTALDH1A1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL19211694 | 0.86 | KMT2A (0.56) | MAPTALDH1A1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL19249950 | 0.85 | ALDH3A1 (0.43) | MAPTALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL7749609 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL492620 | 0.80 | MAPT (0.54) | MAPTALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL25450873 | 0.80 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL4715558 | 0.80 | ALDH1A1 (0.50) | MAPTALDH1A1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14334237 | 0.80 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136870-A9 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136870-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |