Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19224674 | 0.88 | CYP1A2 (0.46) | DHFRTNF | |
| SCHEMBL19879542 | 0.79 | GABRP (0.35) | ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL21891949 | 0.72 | DGKA (0.71) | DGKAALDH1A1MAPTTHRBCNR1 | |
| SCHEMBL20477208 | 0.70 | CYP4F2 (0.48) | TOP2AALDH1A1MAPTDHFRKDM4E | |
| SCHEMBL28571987 | 0.70 | NOS2 (0.48) | MAPK1DHFRKDM4E | |
| SCHEMBL28521019 | 0.70 | TLR8 (0.41) | ALDH1A1MAPTTHRBMAPK1DHFR | |
| SCHEMBL19638 | 0.70 | DGKA (0.67) | DGKAALDH1A1MAPTTHRBCNR1 | |
| SCHEMBL33810 | 0.70 | DGKA (0.74) | DGKAALDH1A1TDP1MAPTMAPK1 | |
| SCHEMBL28076490 | 0.69 | TLR7 (0.41) | ALDH1A1TDP1GAAKDM4E | |
| SCHEMBL410773 | 0.68 | DGKA (0.78) | DGKAALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |