Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207325 | 0.89 | ALDH1A1 (0.38) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL19259345 | 0.88 | CTRC (0.38) | KDM4EMEN1KMT2AMAPTCTRC | |
| SCHEMBL19207290 | 0.80 | ADORA3 (0.39) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL19207276 | 0.80 | P2RY14 (0.44) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL19207284 | 0.80 | MAPT (0.40) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL19207339 | 0.79 | CTRC (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL19207295 | 0.78 | MAP4K4 (0.42) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL19207304 | 0.78 | CNR1 (0.45) | LMNACTRCTP53ALPL | |
| SCHEMBL21573961 | 0.78 | ADORA3 (0.43) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL19259328 | 0.78 | GSK3B (0.37) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411365-B1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| WO-2017133990-A1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-10 | — | — | WO | disclosed |