SCHEMBL19260263

SCHEMBL19260263

O=C(NO)c1ccc(CC2CCc3ccccc3N2)cc1

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.51
HDAC6 Q9UBN7 14/20 0.48
HDAC1 Q13547 10/20 0.48
HDAC8 Q9BY41 11/20 0.47
HDAC2 Q92769 6/20 0.47
HDAC11 Q96DB2 3/20 0.47
HDAC9 Q9UKV0 3/20 0.47
HDAC5 Q9UQL6 3/20 0.47
HDAC10 Q969S8 2/20 0.47
HDAC3 O15379 2/20 0.44
HDAC7 Q8WUI4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16062271 0.86 MTNR1A (0.51) MTNR1A
SCHEMBL19260241 0.80 HDAC1 (0.47) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL10684249 0.79 MTNR1A (0.50) MTNR1A
SCHEMBL19260283 0.79 HDAC6 (0.52) HDAC6HDAC1HDAC8HDAC2HDAC11
SCHEMBL17634157 0.77 MTNR1A (0.46) MTNR1A
SCHEMBL18550600 0.72 HDAC8 (0.38) MTNR1AHDAC6HDAC1HDAC8HDAC2
SCHEMBL25331289 0.70 MTNR1A (0.73) MTNR1A
SCHEMBL3441906 0.70 MTNR1A (0.56) MTNR1A
SCHEMBL700861 0.70 MTNR1A (0.56) MTNR1A
SCHEMBL7149457 0.70 MTNR1A (0.56) MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3416633-A1 TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS The Board of Trustees of the University of Illinois (US) 2018-12-26 EP disclosed
WO-2017142883-A1 TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2017-08-24 WO disclosed