Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL30165714 | 1.00 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL30165717 | 1.00 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL128584 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312498 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312497 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL29941578 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL109755 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312491 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1461350 | 0.96 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1207285 | 0.96 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250222006-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2025-07-10 | — | — | US | disclosed |
| US-20240115580-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2024-04-11 | — | — | US | disclosed |
| US-11878021-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2024-01-23 | — | — | US | disclosed |
| EP-3121169-B1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LAB LTD (SG) | 2022-02-09 | — | — | EP | disclosed |
| US-20210322435-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | Wis Ta Laboratories Ltd. (SG) | 2021-10-21 | — | — | US | disclosed |
| US-11045477-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2021-06-29 | — | — | US | disclosed |
| US-20200261465-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2020-08-20 | — | — | US | disclosed |
| US-20180263999-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2018-09-20 | — | — | US | disclosed |
| US-9980971-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2018-05-29 | — | — | US | disclosed |
| US-20170273986-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2017-09-28 | — | — | US | disclosed |
| US-20130317012-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2013-11-28 | — | — | US | disclosed |
| EP-2057136-B1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LAB LTD (SG) | 2013-05-22 | — | — | EP | disclosed |
| US-8440821-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2013-05-14 | — | — | US | disclosed |
| EP-2457904-A1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | Wista Laboratories Ltd. (SG) | 2012-05-30 | — | — | EP | disclosed |
| EP-2457905-A1 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | Wista Laboratories Ltd. (SG) | 2012-05-30 | — | — | EP | disclosed |
| US-20110294795-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. | 2011-12-01 | — | — | US | disclosed |
| US-7956183-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | WISTA LABORATORIES LTD. (SG) | 2011-06-07 | — | — | US | disclosed |
| US-20090259040-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2009-10-15 | — | — | US | disclosed |
| EP-2057136-A2 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | Wista Laboratories Ltd. (SG) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008007074-A2 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | WISTA LABORATORIES LTD. (SG) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180263999-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20250222006-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20170273986-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20210322435-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-11045477-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20090259040-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | PARK7, SNCA, GRN | APP 212/4885TERT 96/4885APAF1 1844/4885 |
| US-20240115580-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20130317012-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MAPT, TPMT, UROD | APP 38/4885TERT 147/4885APAF1 3787/4885 |
| US-11878021-B2 | Methods of synthesis and/or purification of diaminophenothiazinium compounds | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
| US-20110294795-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MMAB, MB, ABCB7 | APP 3144/4885TERT 743/4885APAF1 3986/4885 |
| US-20200261465-A1 | METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS | MB, TPMT, HBB | APP 237/4885TERT 600/4885APAF1 3734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.