Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylene Blue Cation. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Blue Cation SCHEMBL30367710 | 1.00 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL109755 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312497 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312498 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL12312491 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL128584 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL29941578 | 0.98 | APP (0.57) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1351 | 0.96 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1926028 | 0.96 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 | |
| Methylene Blue Cation SCHEMBL1461350 | 0.96 | APP (0.55) | APPTERTAPAF1EGFRPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250325557-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2025-10-23 | — | — | US | disclosed |
| US-12324810-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | WISTA LABORATORIES LTD. (SG) | 2025-06-10 | — | — | US | disclosed |
| US-20240245700-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2024-07-25 | — | — | US | disclosed |
| US-11951110-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | WISTA LABORATORIES LTD. (SG) | 2024-04-09 | — | — | US | disclosed |
| US-11344558-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | WISTA LABORATORIES LTD. (SG) | 2022-05-31 | — | — | US | disclosed |
| US-20220152038-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2022-05-19 | — | — | US | disclosed |
| US-20190151329-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | WISTA LABORATORIES LTD. (SG) | 2019-05-23 | — | — | US | disclosed |
| US-10188658-B2 | Therapeutic use of diaminophenothiazines | WISTA LABORATORIES LTD. (SG) | 2019-01-29 | — | — | US | disclosed |
| US-20160051559-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2016-02-25 | — | — | US | disclosed |
| US-20160030444-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | WISTA LABORATORIES LTD. (SG) | 2016-02-04 | — | — | US | disclosed |
| US-8710051-B2 | 3,7-diamino-10H-phenothiazine salts and their use | Wis Ta Laboratories Ltd. (SG) | 2014-04-29 | — | — | US | disclosed |
| US-20110118242-A1 | 3,7-DIAMINO-10H-PHINOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. | 2011-05-19 | — | — | US | disclosed |
| US-7888350-B2 | 3,7-diamino-10H-phenothiazine salts and their use | WISTA LABORATORIES LTD. (SG) | 2011-02-15 | — | — | US | disclosed |
| US-20100290986-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | Wis Ta Laboratories Ltd. | 2010-11-18 | — | — | US | disclosed |
| EP-2013191-B1 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LAB LTD (SG) | 2010-08-18 | — | — | EP | disclosed |
| EP-2205245-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | Wista Laboratories Ltd. (SG) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009044127-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | WISTA LABORATORIES LTD. (GB) | 2009-04-09 | — | — | WO | disclosed |
| US-20090054419-A1 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. | 2009-02-26 | — | — | US | disclosed |
| EP-2013191-A2 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | Wista Laboratories Ltd. (SG) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007110627-A2 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250325557-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, APP | APP 3/4885TERT 692/4885APAF1 2904/4885 |
| US-12324810-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | PSEN1, PSEN2, APP | APP 3/4885TERT 628/4885APAF1 2681/4885 |
| US-20110118242-A1 | 3,7-DIAMINO-10H-PHINOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, APP | APP 3/4885TERT 637/4885APAF1 3298/4885 |
| US-20160051559-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, APP | APP 3/4885TERT 692/4885APAF1 2904/4885 |
| US-20100290986-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | QDPR, DDO, HNMT | APP 205/4885TERT 1596/4885APAF1 3476/4885 |
| US-11951110-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | PSEN1, PSEN2, APP | APP 3/4885TERT 692/4885APAF1 2904/4885 |
| US-10188658-B2 | Therapeutic use of diaminophenothiazines | QDPR, DDO, HNMT | APP 290/4885TERT 1810/4885APAF1 3610/4885 |
| US-20160030444-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | QDPR, DDO, HNMT | APP 253/4885TERT 1894/4885APAF1 3537/4885 |
| US-11344558-B2 | 3, 7-diamino-10H-phenothiazine salts and their use | PSEN1, PSEN2, APP | APP 3/4885TERT 692/4885APAF1 2904/4885 |
| US-20220152038-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, APP | APP 3/4885TERT 1123/4885APAF1 2810/4885 |
| US-20190151329-A1 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES | QDPR, DDO, HNMT | APP 253/4885TERT 1894/4885APAF1 3537/4885 |
| US-20240245700-A1 | 3, 7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, APP | APP 3/4885TERT 628/4885APAF1 2681/4885 |
| US-20090054419-A1 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE | PSEN1, PSEN2, HTT | APP 5/4885TERT 339/4885APAF1 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.