Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 4/20 | 0.50 |
| ▸ | GABRD | O14764 | 4/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062550 | 1.00 | GRIN2D (0.57) | GRIN2DGRIN2AGRIN2BGRIN2CGRIN1 | |
| SCHEMBL17065133 | 0.86 | AKR1B10 (0.58) | GRIN2DGRIN2AGRIN2BGRIN2CGRIN1 | |
| SCHEMBL6446879 | 0.82 | GRIN1 (0.49) | GRIN2DGRIN2AGRIN2BGRIN2CGRIN1 | |
| SCHEMBL890668 | 0.81 | AKR1B10 (0.63) | AKR1B10AKR1B1GPBAR1SRD5A2GABRP | |
| SCHEMBL1235822 | 0.81 | AKR1B10 (0.63) | AKR1B10AKR1B1GPBAR1SRD5A2GABRP | |
| SCHEMBL4726566 | 0.81 | CYP19A1 (0.56) | AKR1B10AKR1B1GPBAR1G6PDCYP3A4 | |
| SCHEMBL4927255 | 0.81 | CYP19A1 (0.56) | AKR1B10AKR1B1GPBAR1G6PDCYP3A4 | |
| SCHEMBL3115619 | 0.78 | AKR1B10 (0.60) | AKR1B10AKR1B1GPBAR1SRD5A2GABRP | |
| SCHEMBL3115610 | 0.78 | AKR1B10 (0.60) | AKR1B10AKR1B1GPBAR1SRD5A2GABRP | |
| SCHEMBL9155552 | 0.78 | AKR1B10 (0.58) | AKR1B10AKR1B1GPBAR1SRD5A2GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190321443-A1 | Modulators of MS4A activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2019-10-24 | — | — | US | disclosed |
| WO-2017143036-A1 | MODULATORS OF MS4A ACTIVITY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-24 | — | — | WO | disclosed |