Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 5/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | SNCA | P37840 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19273392 | 0.82 | EGFR (0.35) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL29514362 | 0.81 | ELANE (0.47) | ELANECFTR | |
| SCHEMBL19260864 | 0.80 | DGAT1 (0.34) | DGAT1ELANEEGFRIGF1RSRC | |
| SCHEMBL31050029 | 0.78 | DGAT1 (0.40) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL31710694 | 0.78 | DYRK1A (0.35) | DGAT1ELANEEGFRIGF1RSRC | |
| SCHEMBL21044790 | 0.77 | DGAT1 (0.41) | DGAT1ELANEEGFRIGF1RSRC | |
| SCHEMBL29748840 | 0.77 | DGAT1 (0.41) | DGAT1ELANEEGFRIGF1RSRC | |
| SCHEMBL31710658 | 0.77 | GSK3B (0.36) | DGAT1ELANEEGFRIGF1RSRC | |
| SCHEMBL30848403 | 0.75 | NPC1 (0.36) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL15546774 | 0.74 | POLB (0.39) | DGAT1EGFRIGF1RSRCFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017143134-A1 | FXR MODULATORS AND METHODS OF THEIR USE | ALIOS BIOPHARMA, INC. (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017143134-A1 | FXR MODULATORS AND METHODS OF THEIR USE | ALIOS BIOPHARMA, INC. (US) | 2017-08-24 | — | — | WO | disclosed |