Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27251066 | 0.83 | AR (0.36) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL19260892 | 0.82 | DGAT1 (0.35) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL19273391 | 0.80 | EGFR (0.35) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL31716596 | 0.72 | NPC1 (0.36) | NPC1 | |
| SCHEMBL19689860 | 0.70 | ELANE (0.45) | HTR6 | |
| SCHEMBL30483953 | 0.68 | LTA4H (0.45) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL21474724 | 0.68 | LTA4H (0.45) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL10329164 | 0.68 | RPS6KA5 (0.41) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL1779420 | 0.68 | ALDH1A1 (0.51) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL17883434 | 0.68 | ELANE (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017143134-A1 | FXR MODULATORS AND METHODS OF THEIR USE | ALIOS BIOPHARMA, INC. (US) | 2017-08-24 | — | — | WO | disclosed |