Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | ARG1 | P05089 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29410073 | 1.00 | MAPT (0.54) | MAPTHTTLMNAHSD17B10GRIN1 | |
| SCHEMBL19277838 | 0.88 | ALDH1A1 (0.46) | MAPTHTTLMNAHSD17B10GRIN1 | |
| SCHEMBL21972564 | 0.88 | ALDH1A1 (0.62) | MAPTHTTLMNAPLA2G1BALDH1A1 | |
| SCHEMBL19260915 | 0.88 | MAPT (0.52) | MAPTHTTLMNAHSD17B10GRIN1 | |
| SCHEMBL19277577 | 0.88 | GAA (0.49) | MAPTHTTLMNAHSD17B10GRIN1 | |
| SCHEMBL21972223 | 0.88 | ALDH1A1 (0.56) | MAPTHTTLMNAGRIN1GRIN2B | |
| SCHEMBL19277574 | 0.85 | CYP1A2 (0.58) | MAPTHTTLMNAACHEALDH1A1 | |
| SCHEMBL19260916 | 0.85 | ALDH1A1 (0.61) | MAPTHTTLMNAHSD17B10GRIN1 | |
| SCHEMBL21972579 | 0.85 | ALDH1A1 (0.60) | MAPTHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9819126 | 0.84 | CYP3A4 (0.63) | MAPTHTTLMNAHSD17B10CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416958-B1 | THIOSEMICARBAZIDES AS ANTIFUNGAL COMPOUNDS AND THEIR USES | DANA FARBER CANCER INST INC (US) | 2023-04-19 | — | — | EP | disclosed |
| US-11136291-B2 | Antifungal compounds and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-11136291-B2 | Antifungal compounds and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210147351-A9 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| US-20210147351-A9 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| US-20200140381-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-05-07 | — | — | US | disclosed |
| US-20200140381-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-05-07 | — | — | US | disclosed |
| EP-3416958-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | Dana Farber Cancer Institute, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017143230-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017143230-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147351-A9 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | ERG28, DPM1, CYP51A1 | MAPT 950/4885HTT 1724/4885LMNA 2600/4885 |
| US-20200140381-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | ERG28, DPM1, CYP51A1 | MAPT 950/4885HTT 1724/4885LMNA 2600/4885 |
| US-11136291-B2 | Antifungal compounds and uses thereof | ERG28, DPM1, CYP51A1 | MAPT 950/4885HTT 1724/4885LMNA 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.