Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19277777 | 0.85 | GAA (0.49) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL21972580 | 0.85 | GAA (0.67) | ALDH1A1GAAMEN1KMT2AKDM4E | |
| SCHEMBL21973099 | 0.85 | GAA (0.58) | ALDH1A1GAANOX1MEN1KMT2A | |
| SCHEMBL19277826 | 0.85 | GAA (0.63) | ALDH1A1GAANOX1MEN1KMT2A | |
| SCHEMBL19260918 | 0.85 | MAPT (0.54) | ALDH1A1GAAMEN1KMT2AKDM4E | |
| SCHEMBL29410073 | 0.85 | MAPT (0.54) | ALDH1A1GAAMEN1KMT2AKDM4E | |
| SCHEMBL21972564 | 0.84 | ALDH1A1 (0.62) | ALDH1A1GAAMEN1KMT2AKDM4E | |
| SCHEMBL21972740 | 0.83 | NPC1 (0.59) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL21972737 | 0.83 | GAA (0.56) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL21973098 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1GAAL3MBTL1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136291-B2 | Antifungal compounds and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210147351-A9 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| US-20200140381-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147351-A9 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | ERG28, DPM1, CYP51A1 | ALDH1A1 1944/4885GAA 9/4885L3MBTL1 1401/4885 |
| US-20200140381-A1 | ANTIFUNGAL COMPOUNDS AND USES THEREOF | ERG28, DPM1, CYP51A1 | ALDH1A1 1944/4885GAA 9/4885L3MBTL1 1401/4885 |
| US-11136291-B2 | Antifungal compounds and uses thereof | ERG28, DPM1, CYP51A1 | ALDH1A1 1944/4885GAA 9/4885L3MBTL1 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.