Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19262059 | 0.84 | CCR2 (0.44) | PDE4APDE4BPDE4CPDE4DCCR2 | |
| SCHEMBL19262093 | 0.83 | CCR2 (0.39) | PDE4APDE4BPDE4CPDE4DCCR2 | |
| SCHEMBL16591237 | 0.81 | SLC6A3 (0.33) | PDE4APDE4BPDE4CPDE4DCCR2 | |
| SCHEMBL6994236 | 0.78 | OPRL1 (0.39) | — | |
| SCHEMBL17985231 | 0.77 | EPAS1 (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16591186 | 0.77 | EPAS1 (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1839257 | 0.74 | OPRM1 (0.34) | — | |
| SCHEMBL7985502 | 0.73 | SLC6A2 (0.33) | — | |
| SCHEMBL10270571 | 0.72 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18742483 | 0.71 | NPC1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738642-B2 | Triazolopyridine ether derivatives and their use in neurological and pyschiatric disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-22 | — | — | US | disclosed |