Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | ERN1 | O75460 | 2/20 | 0.65 |
| ▸ | MMP13 | P45452 | 3/20 | 0.62 |
| ▸ | CFD | P00746 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.57 |
| ▸ | FEN1 | P39748 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331526 | 0.91 | MMP13 (0.74) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL5331977 | 0.89 | MMP13 (0.76) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL1926263 | 0.88 | NPC1 (1.00) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL2526264 | 0.87 | NPC1 (0.83) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL9416562 | 0.86 | MMP13 (0.76) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL1927512 | 0.85 | EPHX2 (0.77) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL18773965 | 0.84 | NPC1 (0.64) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL26625669 | 0.84 | MMP13 (0.64) | NPC1RAB9AEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL3029989 | 0.84 | CFD (0.69) | EPHX2NR1H4ALDH1A1SENP1AURKA | |
| SCHEMBL2922655 | 0.83 | MMP13 (0.81) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | NPC1 3792/4885RAB9A 2719/4885EPHX2 4035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.