Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19267422 | 0.81 | DRD2 (0.49) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL24534825 | 0.80 | PLK1 (0.56) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL3091682 | 0.78 | TRPV1 (0.56) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL24835257 | 0.77 | RARB (0.59) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL12894703 | 0.70 | TP53 (0.55) | RARBMEN1KMT2APLK1GAA | |
| SCHEMBL2783032 | 0.69 | CXCR2 (0.47) | MEN1ALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL24835208 | 0.69 | RARB (0.54) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL1761515 | 0.69 | KDM4E (0.45) | MEN1MAPTKMT2A | |
| SCHEMBL24534839 | 0.69 | PLK1 (0.59) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL12642713 | 0.68 | KCNH2 (0.57) | ALDH1A1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943473-B1 | BIPHENYL-ETHYL-PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR MODULATORS FOR THE TREATMENT OF COGNITIVE DISORDERS | ARENA PHARM INC (US) | 2017-08-23 | — | — | EP | disclosed |