Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15723430 | 0.85 | RARB (0.65) | CA1CA2CA9RARBMEN1 | |
| SCHEMBL19267247 | 0.81 | RARB (0.45) | DRD2DRD4DRD3RARBMEN1 | |
| SCHEMBL24835257 | 0.79 | RARB (0.59) | DRD2DRD3RARBMEN1ALDH1A1 | |
| SCHEMBL8884118 | 0.78 | RARB (0.59) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL9215324 | 0.78 | RARB (0.59) | RARBMEN1ALDH1A1RARAMAPT | |
| SCHEMBL23014253 | 0.74 | HDAC6 (0.54) | DRD2DRD4DRD3KMT2ATMEM97 | |
| SCHEMBL15723432 | 0.72 | RARB (0.61) | DRD2DRD4DRD3RARBMEN1 | |
| SCHEMBL7215489 | 0.72 | THRA (0.63) | DRD2DRD4DRD3ALDH1A1TMEM97 | |
| SCHEMBL13760121 | 0.71 | KDM4E (0.62) | CA1CA2CA9ALDH1A1MAPT | |
| SCHEMBL9826808 | 0.71 | ALDH1A1 (0.79) | CA9ALDH1A1MCHR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943473-B1 | BIPHENYL-ETHYL-PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR MODULATORS FOR THE TREATMENT OF COGNITIVE DISORDERS | ARENA PHARM INC (US) | 2017-08-23 | — | — | EP | disclosed |