Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | ESRRG | P62508 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2780994 | 0.91 | HRH3 (0.40) | CXCR2TRPV1ESRRGL3MBTL1HDAC6 | |
| SCHEMBL2781727 | 0.85 | RARB (0.45) | L3MBTL1KMT2ASIGMAR1MAPTKDM4E | |
| SCHEMBL2784683 | 0.80 | FFAR1 (0.47) | L3MBTL1HDAC1HDAC6HDAC8KMT2A | |
| SCHEMBL2781840 | 0.80 | TDP1 (0.41) | HDAC1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL2779102 | 0.76 | MRGPRX4 (0.47) | L3MBTL1KMT2ASIGMAR1MAPTKDM4E | |
| SCHEMBL2780743 | 0.76 | TRPV1 (0.37) | TRPV1 | |
| SCHEMBL2136185 | 0.76 | EPHX2 (0.55) | CXCR2HDAC1HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL2136179 | 0.76 | EPHX2 (0.55) | CXCR2HDAC1HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL2781686 | 0.74 | CYP1A2 (0.48) | L3MBTL1HDAC1HDAC6HDAC8KMT2A | |
| SCHEMBL2780803 | 0.74 | KAT8 (0.51) | L3MBTL1KMT2ASMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136036-A2 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | claimed |
| WO-2010136036-A2 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |