Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1359031 | 0.81 | KMT2A (0.47) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31716007 | 0.81 | CCR1 (0.42) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1928507 | 0.78 | DYRK1A (0.40) | DYRK1AKMT2AHTTALDH1A1MEN1 | |
| SCHEMBL1361039 | 0.78 | DYRK1A (0.40) | DYRK1AKMT2AHTTALDH1A1MEN1 | |
| SCHEMBL31378854 | 0.78 | DYRK1A (0.40) | DYRK1AKMT2AHTTALDH1A1MEN1 | |
| SCHEMBL3114113 | 0.78 | RPS6KA3 (0.37) | ALDH1A1UHRF1KDM4ERPS6KA3MBOAT4 | |
| SCHEMBL534655 | 0.78 | HTT (0.40) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3351306 | 0.74 | LMNA (0.50) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31716595 | 0.73 | SMN1; SMN2 (0.38) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24848530 | 0.73 | PRMT5 (0.53) | DYRK1AKMT2AHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440595-B2 | Fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2185519-B1 | NOVEL FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-10 | — | — | EP | disclosed |
| US-7956188-B2 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| US-20100286199-A1 | NOVEL FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| EP-2185519-A2 | NOVEL FUNGICIDES | Sygenta Participations AG. (CH) | 2010-05-19 | — | — | EP | disclosed |
| US-20100113513-A1 | QUINOLINE DERIVATIVES AS FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| CN-101668424-A | Quinoline derivatives as fungicides | SYNGENTA PARTICIPATIONS AG | 2010-03-10 | — | — | CN | disclosed |
| EP-2139324-A1 | QUINOLINE DERIVATIVES AS FUNGICIDES | Syngeta Participations AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| EP-1817309-B1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-12-23 | — | — | EP | disclosed |
| WO-2009049716-A2 | NOVEL FUNGICIDES | SYGENTA PARTICIPATIONS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| WO-2008110355-A1 | QUINOLINE DERIVATIVES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-09-18 | — | — | WO | disclosed |
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| EP-1817309-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | Syngeta Participations AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006058700-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | NAT1, DPM1, AADAC | DYRK1A 2692/4885KMT2A 66/4885HTT 4197/4885 |
| US-20100286199-A1 | NOVEL FUNGICIDES | CYP51A1, CYP4X1, CYP1B1 | DYRK1A 4038/4885KMT2A 2461/4885HTT 3376/4885 |
| US-20100113513-A1 | QUINOLINE DERIVATIVES AS FUNGICIDES | CYP1A1, CYP4X1, CYP3A7 | DYRK1A 3301/4885KMT2A 1704/4885HTT 3579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.