Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27251064 | 0.82 | CYP17A1 (0.38) | DGAT1CYP17A1NPC1KDM4EBRD4 | |
| SCHEMBL19260864 | 0.81 | DGAT1 (0.34) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL19273392 | 0.80 | EGFR (0.35) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL13168763 | 0.74 | KDM4E (0.45) | NPC1RENHTR6KDM4EBRD4 | |
| SCHEMBL10209154 | 0.73 | PDE10A (0.41) | CYP17A1SCN9AELANE | |
| SCHEMBL31716596 | 0.71 | NPC1 (0.36) | NPC1KDM4E | |
| SCHEMBL16535104 | 0.70 | DGAT1 (0.39) | DGAT1 | |
| SCHEMBL10329164 | 0.70 | RPS6KA5 (0.41) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL21474724 | 0.70 | LTA4H (0.45) | EGFRIGF1RSRCFLT4KDR | |
| SCHEMBL30483953 | 0.70 | LTA4H (0.45) | EGFRIGF1RSRCFLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017143134-A1 | FXR MODULATORS AND METHODS OF THEIR USE | ALIOS BIOPHARMA, INC. (US) | 2017-08-24 | — | — | WO | disclosed |