Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398580 | 0.94 | HSD11B1 (0.60) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL19281133 | 0.92 | KMT2A (0.54) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL31398590 | 0.90 | HSD11B1 (0.55) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL467592 | 0.87 | SIGMAR1 (0.64) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31398594 | 0.87 | HSD11B1 (0.48) | HSD11B1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19281126 | 0.85 | KMT2A (0.48) | HSD11B1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL31398578 | 0.84 | HSD11B1 (0.48) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL31398596 | 0.83 | HSD11B1 (0.47) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL31398597 | 0.83 | HSD11B1 (0.47) | HSD11B1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL17708825 | 0.83 | CHRNA7 (0.50) | HSD11B1KMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731613-A1 | SPIROCYCLIC PARP INHIBITORS AND METHODS OF USE | Valo Health, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024261710-A1 | SPIROCYCLIC PARP INHIBITORS AND METHODS OF USE | VALO HEALTH, INC. (US) | 2024-12-26 | — | — | WO | disclosed |
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |