Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19281135 | 0.92 | HSD11B1 (0.64) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL17708825 | 0.91 | CHRNA7 (0.50) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL467592 | 0.87 | SIGMAR1 (0.64) | KMT2AHDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL31398580 | 0.86 | HSD11B1 (0.60) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL19281126 | 0.83 | KMT2A (0.48) | KMT2AHSD11B1SIGMAR1EPHX2MEN1 | |
| SCHEMBL19030072 | 0.82 | EPHX2 (0.49) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL31398590 | 0.82 | HSD11B1 (0.55) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL14918958 | 0.81 | HSD11B1 (0.59) | KMT2AHSD11B1HDAC8HDAC6HDAC3 | |
| SCHEMBL31398594 | 0.81 | HSD11B1 (0.48) | KMT2AHSD11B1EPHX2MEN1NPSR1 | |
| SCHEMBL19281139 | 0.81 | TRPM8 (0.55) | KMT2ASIGMAR1MEN1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |