Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13118705 | 0.80 | CYP1A2 (0.42) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL21315317 | 0.78 | KMT2A (0.40) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL23645568 | 0.78 | MAPT (0.40) | KMT2ACYP1A2GAAADORA3ALDH1A1 | |
| SCHEMBL5848830 | 0.78 | CYP1A2 (0.41) | KMT2ACYP1A2GAAADORA3ALDH1A1 | |
| SCHEMBL31389413 | 0.76 | KMT2A (0.38) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL3548683 | 0.75 | NPC1 (0.39) | KMT2ACYP1A2GAAGABRPGABRD | |
| SCHEMBL19299890 | 0.75 | KMT2A (0.40) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL19284267 | 0.75 | KMT2A (0.40) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL19299854 | 0.75 | KMT2A (0.40) | KMT2ACYP1A2GAATP53ADORA3 | |
| SCHEMBL23645428 | 0.74 | RAB9A (0.41) | KMT2ACYP1A2GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738063-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | PFIZER INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-10738063-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | PFIZER INC. (US) | 2020-08-11 | — | — | US | disclosed |
| EP-3419979-B1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3419979-B1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER (US) | 2020-01-29 | — | — | EP | disclosed |
| US-20190300546-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER (US) | 2019-10-03 | — | — | US | disclosed |
| US-20190300546-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER (US) | 2019-10-03 | — | — | US | disclosed |
| US-10323042-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | PFIZER INC. (US) | 2019-06-18 | — | — | US | disclosed |
| US-10323042-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | PFIZER INC. (US) | 2019-06-18 | — | — | US | disclosed |
| US-20190055262-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER INC. (US) | 2019-02-21 | — | — | US | disclosed |
| US-20190055262-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER INC. (US) | 2019-02-21 | — | — | US | disclosed |
| EP-3419979-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | Pfizer Inc (US) | 2019-01-02 | — | — | EP | disclosed |
| WO-2017145013-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017145013-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190055262-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | CYP3A5, CYP3A7, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KMT2A 2005/4885CYP1A2 52/4885GAA 1773/4885 |
| US-20190300546-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS | PDE4B, PDE5A, PDE3B | KMT2A 1659/4885CYP1A2 380/4885GAA 1441/4885 |
| US-10738063-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | PDE4B, PDE5A, PDE3B | KMT2A 1659/4885CYP1A2 380/4885GAA 1441/4885 |
| US-10323042-B2 | 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | CYP3A5, CYP3A7, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KMT2A 2005/4885CYP1A2 52/4885GAA 1773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.