Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12762846 | 0.88 | CYP3A4 (0.48) | CYP3A4MAP4K1PRMT5WDR77ABL1 | |
| SCHEMBL21919959 | 0.88 | MTNR1A (0.43) | CYP3A4MAP4K1PRMT5WDR77ABL1 | |
| SCHEMBL24565963 | 0.81 | PRMT5 (0.46) | CYP3A4MAP4K1PRMT5WDR77ABL1 | |
| SCHEMBL15934118 | 0.80 | CYP3A4 (0.46) | CYP3A4PRMT5WDR77ALOX5APMTNR1A | |
| SCHEMBL14032289 | 0.78 | MET (0.42) | PRMT5WDR77ABL1 | |
| SCHEMBL24005713 | 0.77 | PRMT5 (0.40) | CYP3A4MAP4K1PRMT5WDR77CYP2C9 | |
| SCHEMBL19787915 | 0.77 | BRD4 (0.47) | CYP3A4PRMT5WDR77CYP2C9CYP2C19 | |
| SCHEMBL24012829 | 0.76 | PRMT5 (0.41) | CYP3A4MAP4K1PRMT5WDR77ABL1 | |
| SCHEMBL15932318 | 0.76 | ALOX5AP (0.44) | CYP3A4MAP4K1PRMT5WDR77ABL1 | |
| SCHEMBL18634090 | 0.76 | PDPK1 (0.35) | CYP3A4MAP4K1ABL1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |