Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23374543 | 0.84 | PARP1 (0.44) | PARP1HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL15472207 | 0.84 | PARP1 (0.41) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL22548658 | 0.84 | PARP1 (0.41) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL21572675 | 0.80 | PARP1 (0.41) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL23260541 | 0.80 | PARP1 (0.47) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL20627467 | 0.78 | F2 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL18405263 | 0.78 | PARP1 (0.46) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL20313308 | 0.78 | PARP1 (0.46) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL1348921 | 0.78 | GPR52 (0.56) | PARP1HDAC8HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL13782590 | 0.78 | HDAC1 (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086892-A1 | INTERLEUKIN 4 (IL4)-INDUCED GENE 1 INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| US-9748497-B2 | Electronic device including a diazachrysene derivative | E I DU PONT DE NEMOURS AND COMPANY (US) | 2017-08-29 | — | — | US | disclosed |